activity
20102023
most citedIntrinsic limits to gene regulation by global crosstalk

90 citations · 176 across the 5 of their papers we have counts for

collaborators

5 papers

cs.CV2023

AI-based automated active learning for discovery of hidden dynamic processes: A use case in light microscopy

Nils Friederich, Angelo Yamachui Sitcheu, Oliver Neumann +4

In the biomedical environment, experiments assessing dynamic processes are primarily performed by a human acquisition supervisor. Contemporary implementations of such experiments f…

q-bio.SC2018★ 36 cited

Receptor crosstalk improves concentration sensing of multiple ligands

Martin Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko +5

Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface…

q-bio.PE2016★ 44 cited

Evolution of new regulatory functions on biophysically realistic fitness landscapes

Tamar Friedlander, Roshan Prizak, Nicholas H. Barton +1

Regulatory networks consist of interacting molecules with a high degree of mutual chemical specificity. How can these molecules evolve when their function depends on maintenance of…

q-bio.MN2015★ 90 cited

Intrinsic limits to gene regulation by global crosstalk

Tamar Friedlander, Roshan Prizak, Călin C. Guet +2

Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a…

nlin.AO2010★ 6 cited

Opinion formation and cyclic dominance in adaptive networks

Güven Demirel, Roshan Prizak, P. Nitish Reddy +1

The Rock-Paper-Scissors(RPS) game is a paradigmatic model for cyclic dominance in biological systems. Here we consider this game in the social context of competition between opinio…