340 citations · 1k across the 21 of their papers we have counts for
4 papers · 1 filter
A statistical framework for joint eQTL analysis in multiple tissues
Timothée Flutre, Xiaoquan Wen, Jonathan Pritchard +1
Mapping expression Quantitative Trait Loci (eQTLs) represents a powerful and widely-adopted approach to identifying putative regulatory variants and linking them to specific genes.…
Small World MCMC with Tempering: Ergodicity and Spectral Gap
Yongtao Guan, Matthew Stephens
When sampling a multi-modal distribution , $x\in \rr^d$, a Markov chain with local proposals is often slowly mixing; while a Small-World sampler \citep{guankrone} -- a Markov…
Polygenic Modeling with Bayesian Sparse Linear Mixed Models
Xiang Zhou, Peter Carbonetto, Matthew Stephens
Both linear mixed models (LMMs) and sparse regression models are widely used in genetics applications, including, recently, polygenic modeling in genome-wide association studies. T…
Integrated analysis of variants and pathways in genome-wide association studies using polygenic models of disease
Peter Carbonetto, Matthew Stephens
Many common diseases are highly polygenic, modulated by a large number genetic factors with small effects on susceptibility to disease. These small effects are difficult to map rel…