302 citations · 391 across the 14 of their papers we have counts for
5 papers · 1 filter
RecA-mediated homology search as a nearly optimal signal detection system
Yonatan Savir, Tsvi Tlusty
Homologous recombination facilitates the exchange of genetic material between homologous DNA molecules. This crucial process requires detecting a specific homologous DNA sequence w…
Optimal Design of a Molecular Recognizer: Molecular Recognition as a Bayesian Signal Detection Problem
Yonatan Savir, Tsvi Tlusty
Numerous biological functions-such as enzymatic catalysis, the immune response system, and the DNA-protein regulatory network-rely on the ability of molecules to specifically recog…
Molecular Recognition as an Information Channel: The Role of Conformational Changes
Yonatan Savir, Tsvi Tlusty
Molecular recognition, which is essential in processing information in biological systems, takes place in a crowded noisy biochemical environment and requires the recognition of a…
Cross-species analysis traces adaptation of Rubisco towards optimality in a low dimensional landscape
Yonatan Savir, Elad Noor, Ron Milo +1
Rubisco, probably the most abundant protein in the biosphere, performs an essential part in the process of carbon fixation through photosynthesis thus facilitating life on earth. D…
Conformational Proofreading: The Impact of Conformational Changes on the Specificity of Molecular Recognition
Yonatan Savir, Tsvi Tlusty
To perform recognition, molecules must locate and specifically bind their targets within a noisy biochemical environment with many look-alikes. Molecular recognition processes, esp…