Boltzmann-Aligned Inverse Folding Model as a Predictor of Mutational Effects on Protein-Protein Interactions

Xiaoran Jiao, Weian Mao, Wengong Jin +3

Predicting the change in binding free energy ($\hat{I}”\hat{I}”G$) is crucial for understanding and modulating protein-protein interactions, which are critical in drug design. Due to the scarc…