2 papers
q-bio.CB2012
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination
Philippos K. Tsourkas, Somkanya C. Das, Paul Yu-Yang +3
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination".…
q-bio.CB2010
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering
Philippos K. Tsourkas, Wanli Liu, Somkanya C Das +2
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to…