41 citations · 113 across the 5 of their papers we have counts for
3 papers · 1 filter
Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
Sanchari Bhattacharyyaa, Shimon Bershtein, Bharat V. Adkara +2
The relationship between sequence variation and phenotype is poorly understood. Here we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phe…
Substrate inhibition imposes fitness penalty at high protein stability
Bharat V. Adkar, Sanchari Bhattacharyya, Amy I. Gilson +2
Proteins are only moderately stable. It has long been debated whether this narrow range of stabilities is solely a result of neutral drift towards lower stability or purifying sele…
An internal disulfide locks a misfolded aggregation-prone intermediate in cataract-linked mutants of human γD-crystallin
Eugene Serebryany, Jaie C. Woodard, Bharat V. Adkar +3
Considerable mechanistic insight has been gained into amyloid aggregation; however, a large class of non-amyloid protein aggregates are considered 'amorphous,' and in most cases li…