42 citations · 169 across the 26 of their papers we have counts for
10 papers · 1 filter
A strategy on prion AGAAAAGA amyloid fibril molecular modelling
Jiapu Zhang, David D. W. Liu
X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy are two powerful tools to determine the protein 3D structure. However, not all proteins can be successfully…
Molecular Dynamics Studies on the Structural Stability of Wild-Type Rabbit Prion Protein: Surface Electrostatic Charge Distributions
Jiapu Zhang
Prion diseases cover a large range of neurodegenerative diseases in humans and animals, which are invariably fatal and highly infectious. By now there have not been some effective…
Canonical Duality Theory for Solving Minimization Problem of Rosenbrock Function
David Y. Gao, Jiapu Zhang
This paper presents a canonical duality theory for solving nonconvex minimization problem of Rosenbrock function. Extensive numerical results show that this benchmark test problem…
Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins
Jiapu Zhang
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease,…
A novel canonical dual computational approach for prion AGAAAAGA amyloid fibril molecular modeling
Jiapu Zhang, David Y. Gao, Johh Yearwood
Many experimental studies have shown that the prion AGAAAAGA palindrome hydrophobic region (113-120) has amyloid fibril forming properties and plays an important role in prion dise…
Canonical dual theory applied to a Lennard-Jones potential minimization problem
Jiapu Zhang
The simplified Lennard-Jones (LJ) potential minimization problem is w…
The Lennard-Jones Potential Minimization Problem for Prion AGAAAAGA Amyloid Fibril Molecular Modeling
Jiapu Zhang
The simplified Lennard-Jones (LJ) potential minimization problem is minimize f(x)=4\sum_{i=1}^N \sum_{j=1,j<i}^N (τ_{ij}^{-6} -τ_{ij}^{-3}) subject to x\in \mathbb{R}^n, where $τ_{…
The nature of the infectious agents: PrP models of resistant species to prion diseases (dog, rabbit and horses)
Jiapu Zhang
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. By now there have not been some effective therapeutic approaches…
A Simple But Effective Canonical Dual Theory Unified Algorithm for Global Optimization
Jiapu Zhang
Numerical global optimization methods are often very time consuming and could not be applied for high-dimensional nonconvex/nonsmooth optimization problems. Due to the nonconvexity…
The Structural Stability of Wild-type Horse Prion Protein - Molecular Dynamics Studies
Jiapu Zhang
Prion diseases {\it (e.g. Creutzfeldt-Jakob disease (CJD), variant CJD (vCJD), Gerstmann-Strussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI) and Kuru…