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Molecular dynamics and optimization studies of horse prion protein wild type and its S167D mutant
Jiapu Zhang
Prion diseases or called transmissible spongiform encephalopathies are fatal neurodegenerative diseases characterised by the accumulation of an abnormal prion protein isoform (rich…
The polar clasps of a bank vole PrP(168--176) prion protofibril revisiting
Jiapu Zhang
On 2018-01-17 two electron crystallography structures (with PDB entries 6AXZ, 6BTK) on a prion protofibril of bank vole PrP(168-176) (a segment in the PrP 2-2 loop) were rele…
Molecular Dynamics Studies of the Bufallo Prion Protein Structured Region at Higher Temperatures
Jiapu Zhang
Molecular dynamics (MD) studies of buffalo prion protein (BufPrP) [Zhang JP et al.(2016) J Biomol Struct Dyn 34(4):762-777] showed that the structure of this protein is…
Molecular Dynamics Studies of Dog Prion Protein Wild-type and Its D159N Mutant
Jiapu Zhang
Prion diseases (e.g. "mad cow" disease in cattle, chronic wasting disease in deer and elk, CJD in humans) have been a major public health concern affecting humans and almost all an…