40 citations · 111 across the 5 of their papers we have counts for
5 papers
Computational tools for assessing gene therapy under branching process models of mutation
Timothy C Stutz, Janet S. Sinsheimer, Mary Sehl +1
Multitype branching processes are ideal for studying the population dynamics of stem cell populations undergoing mutation accumulation over the years following transplant. In such…
OPENMENDEL: A Cooperative Programming Project for Statistical Genetics
Hua Zhou, Janet S. Sinsheimer, Christopher A. German +12
Statistical methods for genomewide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed a…
BioSimulator.jl: Stochastic simulation in Julia
Alfonso Landeros, Timothy Stutz, Kevin L. Keys +4
Biological systems with intertwined feedback loops pose a challenge to mathematical modeling efforts. Moreover, rare events, such as mutation and extinction, complicate system dyna…
Assessing phenotypic correlation through the multivariate phylogenetic latent liability model
Gabriela B. Cybis, Janet S. Sinsheimer, Trevor Bedford +3
Understanding which phenotypic traits are consistently correlated throughout evolution is a highly pertinent problem in modern evolutionary biology. Here, we propose a multivariate…
Reuse, recycle, reweigh: Combating influenza through efficient sequential Bayesian computation for massive data
Jennifer A. Tom, Janet S. Sinsheimer, Marc A. Suchard
Massive datasets in the gigabyte and terabyte range combined with the availability of increasingly sophisticated statistical tools yield analyses at the boundary of what is computa…