163 citations · 579 across the 13 of their papers we have counts for
14 papers
Artificial confocal microscopy for deep label-free imaging
Xi Chen, Mikhail E. Kandel, Shenghua He +8
Widefield microscopy methods applied to optically thick specimens are faced with reduced contrast due to spatial crosstalk, in which the signal at each point is the result of a sup…
Synthetic aperture interference light (SAIL) microscopy for high-throughput label-free imaging
Chenfei Hu, Mikhail E. Kandel, Young Jae Lee +1
Quantitative phase imaging (QPI) is a valuable label-free modality that has gained significant interest due to its wide potentials, from basic biology to clinical applications. Mos…
Diffraction as scattering under the Born approximation
Neha Goswami, Gabriel Popescu
Light diffraction at an aperture is a basic problem that has generated a tremendous amount of interest in optics. Some of the most significant diffraction results are the Fresnel-K…
Computational interference microscopy enabled by deep learning
Yuheng Jiao, Yuchen R. He, Mikhail E. Kandel +3
Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to…
Multiscale assay of unlabeled neurite dynamics using phase imaging with computational specificity (PICS)
Mikhail E. Kandel, Eunjae Kim, Young Jae Lee +3
Primary neuronal cultures have been widely used to study neuronal morphology, neurophysiology, neurodegenerative processes, and molecular mechanism of synaptic plasticity underlyin…
Wolf phase tomography (WPT) of transparent structures using partially coherent illumination
Xi Chen, Mikhail E. Kandel, Chenfei Hu +2
Diffraction tomography using coherent holographic imaging has been proposed by Emil Wolf in 1969 to extract 3D information from transparent, inhomogeneous objects. At the same time…
Phase Imaging with Computational Specificity (PICS) for measuring dry mass changes in sub-cellular compartments
Mikhail E. Kandel, Yuchen R. He, Young Jae Lee +7
Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continu…
Quantifying myelin in brain tissue using color spatial light interference microscopy (cSLIM)
Michael Fanous, Megan P. Caputo, Young Jae Lee +7
Deficient myelination of the brain is associated with neurodevelopmental delays, particularly in high-risk infants, such as those born small in relation to their gestational age (S…
Bond-Selective Transient Phase Microscopy
Delong Zhang, Lu Lan, Yeran Bai +4
Phase-contrast microscopy converts the optical phase introduced by transparent, unlabeled specimens into modulation in the intensity image. Modern phase imaging techniques are capa…
Quantitative Histopathology of Stained Tissues using Color Spatial Light Interference Microscopy (cSLIM)
Hassaan Majeed, Adib Keikhosravi, Mikhail E. Kandel +6
Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase ima…
Magnified Image Spatial Spectrum (MISS) microscopy for nanometer and millisecond scale label-free imaging
Hassaan Majeed, Lihong Ma, Young Jae Lee +5
Label-free imaging of rapidly moving, sub-diffraction sized structures has important applications in both biology and material science, as it removes the limitations associated wit…
Label-free quantitative screening of breast tissue using Spatial Light Interference Microscopy (SLIM)
Hassaan Majeed, Tan Huu Nguyen, Mikhail Eugene Kandel +2
Breast cancer is the most common type of cancer among women worldwide. The standard histopathology of breast tissue, the primary means of disease diagnosis, involves manual microsc…
Optical excitation and detection of neuronal activity
Chenfei Hu, Richard Sam, Mingguang Shan +6
Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optica…
Effective Temperature of Red Blood Cell Membrane Fluctuations
Eyal Ben-Isaac, YongKeun Park, Gabriel Popescu +3
Biologically driven non-equilibrium fluctuations are often characterized by their non-Gaussianity or by an "effective temperature", which is frequency dependent and higher than the…