39 citations · 157 across the 21 of their papers we have counts for
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Generalized Method of Moments Estimation for Stochastic Models of DNA Methylation Patterns
Alexander Lück, Verena Wolf
With recent advances in sequencing technologies, large amounts of epigenomic data have become available and computational methods are contributing significantly to the progress of…
A Stochastic Automata Network Description for Spatial DNA-Methylation Models
Alexander Lück, Verena Wolf
DNA methylation is an important biological mechanism to regulate gene expression and control cell development. Mechanistic modeling has become a popular approach to enhance our und…
Rejection-Based Simulation of Non-Markovian Agents on Complex Networks
Gerrit Großmann, Luca Bortolussi, Verena Wolf
Stochastic models in which agents interact with their neighborhood according to a network topology are a powerful modeling framework to study the emergence of complex dynamic patte…
Bounding Mean First Passage Times in Population Continuous-Time Markov Chains
Michael Backenköhler, Luca Bortolussi, Verena Wolf
We consider the problem of bounding mean first passage times for a class of continuous-time Markov chains that captures stochastic interactions between groups of identical agents.…
Control Variates for Stochastic Simulation of Chemical Reaction Networks
Michael Backenköhler, Luca Bortolussi, Verena Wolf
Stochastic simulation is a widely used method for estimating quantities in models of chemical reaction networks where uncertainty plays a crucial role. However, reducing the statis…
A Hybrid HMM Approach for the Dynamics of DNA Methylation
Charalampos Kyriakopoulos, Pascal Giehr, Alexander Lück +2
The understanding of mechanisms that control epigenetic changes is an important research area in modern functional biology. Epigenetic modifications such as DNA methylation are in…