39 citations · 157 across the 21 of their papers we have counts for
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Generalized Method of Moments Estimation for Stochastic Models of DNA Methylation Patterns
Alexander Lück, Verena Wolf
With recent advances in sequencing technologies, large amounts of epigenomic data have become available and computational methods are contributing significantly to the progress of…
A Stochastic Automata Network Description for Spatial DNA-Methylation Models
Alexander Lück, Verena Wolf
DNA methylation is an important biological mechanism to regulate gene expression and control cell development. Mechanistic modeling has become a popular approach to enhance our und…
A Hybrid HMM Approach for the Dynamics of DNA Methylation
Charalampos Kyriakopoulos, Pascal Giehr, Alexander Lück +2
The understanding of mechanisms that control epigenetic changes is an important research area in modern functional biology. Epigenetic modifications such as DNA methylation are in…
A Stochastic Model for the Formation of Spatial Methylation Patterns
Alexander Lück, Pascal Giehr, Jörn Walter +1
DNA methylation is an epigenetic mechanism whose important role in development has been widely recognized. This epigenetic modification results in heritable changes in gene express…
H(O)TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data
Charalampos Kyriakopoulos, Pascal Giehr, Verena Wolf
Methylation and hydroxylation of cytosines to form 5-methylcytosine (5mC) and 5-droxymethylcytosine (5hmC) belong to the most important epigenetic modifications and their vital rol…