5 papers
Direct optimization of the probability of lesion origin in proton treatment planning for low-grade glioma patients
Tim Ortkamp, Habiba Sallem, Semi Harrabi +4
In proton therapy of low-grade glioma (LGG) patients, contrast-enhancing brain lesions (CEBLs) on magnetic resonance imaging are considered predictive of late radiation-induced les…
Trading robustness: a scenario-free approach to robust Multi-Criteria Optimization for Treatment Planning
Remo Cristoforetti, Philipp Süss, Tobias Becher +1
Treatment planning in radiotherapy is inherently a multi-criteria optimization (MCO) problem. Traditionally, the treatment's robustness is not formulated as a part of this decision…
LET-modifying joint optimization for mixed-modality photon-proton treatment planning
Lisa Seckler, Amit Ben Antony Bennan, Niklas Wahl
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variatio…
An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose
Simona Facchiano, Ramon Ortiz, Remo Cristoforetti +4
Nanodosimetry relates Ionization Detail (ID) and ionization parameters (Ip) to biological endpoints relevant for charged-particle radiotherapy. This supports a more physics-based m…
Scenario-free robust optimization algorithm for IMRT and IMPT treatment planning
Remo Cristoforetti, Jennifer Josephine Hardt, Niklas Wahl
Robust treatment planning algorithms for Intensity Modulated Proton Therapy (IMPT) and Intensity Modulated Radiation Therapy (IMRT) allow for uncertainty reduction in the delivered…