4 papers
Emergent frequency-dependent selection predicts mutation outcomes in complex ecological communities
Shing Yan Li, Zhijie Feng, Akshit Goyal +1
Ecological interactions can dramatically alter evolutionary outcomes in complex communities. Yet, the framework of population genetics largely neglects interactions from a species-…
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
A theory of ecological invasions and its implications for eco-evolutionary dynamics
Zhijie Feng, Emmy Blumenthal, Pankaj Mehta +1
Predicting the outcomes of species invasions is a central goal of ecology, a task made especially challenging due to ecological feedbacks. To address this, we develop a general the…
Balancing the cellular budget: lessons in metabolism from microbes to cancer
B. Vibishan, Mohit Kumar Jolly, Akshit Goyal
Cancer cells are often seen to prefer glycolytic metabolism over oxidative phosphorylation even in the presence of oxygen-a phenomenon termed the Warburg effect. Despite significan…