4 papers · 1 filter
Nonparametric estimation of the total treatment effect with multiple outcomes in the presence of terminal events
Jessica Gronsbell, Zachary R. McCaw, Isabelle-Emmanuella Nogues +4
As standards of care advance, patients are living longer and once-fatal diseases are becoming manageable. Clinical trials increasingly focus on reducing disease burden, which can b…
Resilience Measures for the Surrogate Paradox
Emily Hsiao, Lu Tian, Layla Parast
Surrogate markers are often used in clinical trials to evaluate treatment effects when primary outcomes are costly, invasive, or take a long time to observe. However, reliance on s…
Sampling-based federated inference for M-estimators with non-smooth objective functions
Xiudi Li, Lu Tian, Tianxi Cai
We propose a novel sampling-based federated learning framework for statistical inference on M-estimators with non-smooth objective functions, which frequently arise in modern stati…
Model-free Approach to Evaluate a Censored Intermediate Outcome as a Surrogate for Overall Survival
Xuan Wang, Tianxi Cai, Lu Tian +1
Clinical trials or studies oftentimes require long-term and/or costly follow-up of participants to evaluate a novel treatment/drug/vaccine. There has been increasing interest in th…