4 papers
Monte Carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in normal and cancer cells
Subhadip Raychaudhuri, Somkanya C Das
Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in…
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination
Philippos K. Tsourkas, Somkanya C. Das, Paul Yu-Yang +3
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination".…
Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells
Joanna Skommer, Somkanya C Das, Arjun Nair +2
Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-st…
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering
Philippos K. Tsourkas, Wanli Liu, Somkanya C Das +2
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to…