158 citations · 240 across the 4 of their papers we have counts for
4 papers
Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells
Joanna Skommer, Somkanya C Das, Arjun Nair +2
Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-st…
Timing is everything: on the stochastic origins of cell-to-cell variability in cancer cell death decisions
Joanna Skommer, Subhadip Raychaudhuri, Donald Wlodkowic
The diversity of cell populations is regulated by extracellular and intracellular variability. The latter includes genetic, epigenetic and stochastic variability, all contributing…
Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death
Joanna Skommer, Tom Brittain, Subhadip Raychaudhuri
BH3 mimetics have been proposed as new anticancer therapeutics. They target anti-apoptotic Bcl-2 proteins, up-regulation of which has been implicated in the resistance of many canc…
Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death
Subhadip Raychaudhuri, Joanna Skommer, Kristen Henty +2
In the past few years, overwhelming evidence has accrued that a high level of expression of the protein neuroglobin protects neurons in vitro, in animal models, and in humans, agai…