2 papers
physics.optics2026
Sub-micromolar imaging of intrinsic chromophores by two-photon photothermal microscopy captures mitochondrial response to chemotherapy
Nathaniel Hai, Chinmayee Vallabh Prabhu Dessai, Dingcheng Sun +4
Intracellular chromophores (e.g., NADH and FAD) play a central role in regulation of cellular metabolism. Though autofluorescence has been extensively used for label-free mapping o…
physics.optics2026
Mid-wave infrared photothermal microscopy for molecular and metabolic imaging in deep tissues and spheroids
Mingsheng Li, Yuhao Yuan, Guangrui Ding +11
High-resolution chemical imaging within deep tissues and intact spheroids remains a grand challenge. Here, we introduce mid-wave infrared photothermal (MWIP) microscopy operating i…