Molecular Dynamics Studies of Changes in the DNA- Structure as Result of Interactions with Cisplatin

Alexander N. Issanin, Walter Langel, Patrick J. Bednarski

The 3'-monofunctional adduct of cisplatin and d(CTCTG*G*TCTC)2 duplex DNA in solvent with explicit counter ions and water molecules were subjected to MD- simulation with AMBER forc…