5 papers · 1 filter
Cell-cell adhesion cannot sustain extended follower streams in a minimal non-local model of leader-follower migration
Thomas Jun Jewell, Samuel W. S. Johnson, Ruth E. Baker +1
Cell-cell adhesion is widely hypothesised to maintain cohesion within the long streams of follower cells that trail leader subpopulations during collective migration, including in…
The spontaneous emergence of leaders and followers in a mathematical model of cranial neural crest cell migration
Samuel W. S. Johnson, Ruth E. Baker, Philip K. Maini
Many agent-based mathematical models of cranial neural crest cell (CNCC) migration impose a binary phenotypic partition of cells into either leaders or followers. In such models, t…
An energy-based mathematical model of actin-driven protrusions in eukaryotic chemotaxis
Samuel W. S. Johnson, Maddy Parsons, Ruth E. Baker +1
In eukaryotic cell chemotaxis, cells extend and retract transient actin-driven protrusions at their membrane that facilitate both the detection of external chemical gradients and d…
Collective Invasion: When does domain curvature matter?
Joseph J. Pollacco, Ruth E. Baker, Philip K. Maini
Real-world cellular invasion processes often take place in curved geometries. Such problems are frequently simplified in models to neglect the curved geometry in favour of computat…
Phenotypic switching mechanisms determine the structure of cell migration into extracellular matrix under the `go-or-grow' hypothesis
Rebecca M. Crossley, Kevin J. Painter, Tommaso Lorenzi +2
A fundamental feature of collective cell migration is phenotypic heterogeneity which, for example, influences tumour progression and relapse. While current mathematical models ofte…