247 citations · 492 across the 7 of their papers we have counts for
7 papers
Evolutionary mismatch and the role of GxE interactions in human disease
Amanda J. Lea, Andrew G. Clark, Andrew W. Dahl +18
Globally, we are witnessing the rise of complex, non-communicable diseases (NCDs) related to changes in our daily environments. Obesity, asthma, cardiovascular disease, and type 2…
Testing Causality in Scientific Modelling Software
Andrew G. Clark, Michael Foster, Benedikt Prifling +4
From simulating galaxy formation to viral transmission in a pandemic, scientific models play a pivotal role in developing scientific theories and supporting government policy decis…
An empirical Bayes approach to estimating dynamic models of co-regulated gene expression
Sara Venkatraman, Sumanta Basu, Andrew G. Clark +3
Time-course gene expression datasets provide insight into the dynamics of complex biological processes, such as immune response and organ development. It is of interest to identify…
Behavioral individuality reveals genetic control of phenotypic variability
Julien F. Ayroles, Sean M. Buchanan, Chelsea Jenney +5
Variability is ubiquitous in nature and a fundamental feature of complex systems. Few studies, however, have investigated variance itself as a trait under genetic control. By focus…
Neutral genomic regions refine models of recent rapid human population growth
Elodie Gazave, Li Ma, Diana Chang +8
Human populations have experienced dramatic growth since the Neolithic revolution. Recent studies that sequenced a very large number of individuals observed an extreme excess of ra…
Characterizing the infection-induced transcriptome of Nasonia vitripennis reveals a preponderance of taxonomically-restricted immune genes
Timothy B. Sackton, John H. Werren, Andrew G. Clark
The innate immune system in insects consists of a conserved core signaling network and rapidly diversifying effector and recognition components, often containing a high proportion…
Distortion of genealogical properties when the sample is very large
Anand Bhaskar, Andrew G. Clark, Yun S. Song
Study sample sizes in human genetics are growing rapidly, and in due course it will become routine to analyze samples with hundreds of thousands if not millions of individuals. In…