49 citations · 210 across the 23 of their papers we have counts for
25 papers
Harmonized Estimation of Subgroup-Specific Treatment Effects in Randomized Trials: The Use of External Control Data
Daniel Schwartz, Riddhiman Saha, Steffen Ventz +1
Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses o…
Sensitivity Analyses of Clinical Trial Designs: Selecting Scenarios and Summarizing Operating Characteristics
Larry Han, Andrea Arfe, Lorenzo Trippa
The use of simulation-based sensitivity analyses is fundamental to evaluate and compare candidate designs for future clinical trials. In this context, sensitivity analyses are espe…
Bayesian Multi-Arm De-Intensification Designs
Steffen Ventz, Lorenzo Trippa
In recent years new cancer treatments improved survival in multiple histologies. Some of these therapeutics, and in particular treatment combinations, are often associated with sev…
Cross-Study Replicability in Cluster Analysis
Lorenzo Masoero, Emma Thomas, Giovanni Parmigiani +2
In cancer research, clustering techniques are widely used for exploratory analyses and dimensionality reduction, playing a critical role in the identification of novel cancer subty…
Prediction of Hereditary Cancers Using Neural Networks
Zoe Guan, Giovanni Parmigiani, Danielle Braun +1
Family history is a major risk factor for many types of cancer. Mendelian risk prediction models translate family histories into cancer risk predictions based on knowledge of cance…
Approximating the Operating Characteristics of Bayesian Uncertainty Directed Trial Designs
Marta Bonsaglio, Sandra Fortini, Steffen Ventz +1
Bayesian response adaptive clinical trials are currently evaluating experimental therapies for several diseases. Adaptive decisions, such as pre-planned variations of the randomiza…