165 citations · 243 across the 12 of their papers we have counts for
3 papers · 1 filter
Clinical trials impacted by the COVID-19 pandemic: Adaptive designs to the rescue?
Cornelia Ursula Kunz, Silke Jörgens, Frank Bretz +6
Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the Wo…
Model Selection versus Model Averaging in Dose Finding Studies
Kirsten Schorning, Björn Bornkamp, Frank Bretz +1
Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug. An important decision is…
Response-adaptive dose-finding under model uncertainty
Björn Bornkamp, Frank Bretz, Holger Dette +1
Dose-finding studies are frequently conducted to evaluate the effect of different doses or concentration levels of a compound on a response of interest. Applications include the in…