4 papers
A method for comparing inferred evolutionary accumulation dynamics across covariates and model structures
Jakob Fernø, Jakob Fernø, Michelle B. Verstraaten +5
In this note we describe a method for comparing inferred dynamics in evolutionary accumulation models (EvAMs). These models involve the acquisition of multiple, potentially codepen…
A structural causal framework for interventions on evolutionary accumulation models
Ramon Diaz-Uriarte, Ãñigo RÃos-Arroyo, Iain G. Johnston
Evolutionary accumulation models (EvAMs), also known as cancer progression models (CPMs), infer dependencies in the order of accumulation of mutations during tumor progression from…
Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance
Jessica Renz, Kazeem A. Dauda, Olav N. L. Aga +4
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology an…
A picture guide to cancer progression and monotonic accumulation models: evolutionary assumptions, plausible interpretations, and alternative uses
Ramon Diaz-Uriarte, Iain G. Johnston
Cancer progression and monotonic accumulation models were developed to discover dependencies in the irreversible acquisition of binary traits from cross-sectional data. They have b…