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math.NA2026
Efficient and well-conditioned ghost-point discretization of boundary operators on unfitted domains
Armando Coco, Alessandro Coclite, Stéphane Clain +1
Unfitted boundary methods are widely used to numerically solve partial differential equations (PDEs) on irregular domains, avoiding the computational burden of generating boundary-…
math.NA2025
Mathematical modeling and sensitivity analysis of hypoxia-activated drugs
Alessandro Coclite, Riccardo Montanelli Eccher, Luca Possenti +2
Hypoxia-activated prodrugs offer a promising strategy for targeting oxygen-deficient regions in solid tumors, which are often resistant to conventional therapies. However, modeling…
math.NA2025
Neural Preconditioning via Krylov Subspace Geometry
Nunzio Dimola, Alessandro Coclite, Paolo Zunino
We propose a geometry-aware strategy for training neural preconditioners tailored to parametrized linear systems arising from the discretization of mixed-dimensional partial differ…