most citedDesigning a Bayesian adaptive clinical trial to evaluate novel mechanical ventilation strategies in acute respiratory failure using Integrated Nested Laplace Approximations

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stat.AP2023★ 1 cited

Designing a Bayesian adaptive clinical trial to evaluate novel mechanical ventilation strategies in acute respiratory failure using Integrated Nested Laplace Approximations

Reyhaneh Hosseini, Ziming Chen, Ewan Goligher +7

Background: We aimed to design a Bayesian adaption trial through extensive simulations to determine values for key design parameters, demonstrate error rates, and establish the exp…