8 papers
Intrinsic stochasticity in cell polarity and contact inhibition of locomotion
Mariia Kryvoruchko, Brian A. Camley
When cells collide, they often exhibit "contact inhibition of locomotion" (CIL), a behavior in which cells repolarize and migrate away from the site of contact. Experimental CIL ou…
Divergence of detachment forces in the finite Voronoi model
Wei Wang, Brian A. Camley
Detachment and fracture are central to many tissue-level processes, but they are challenging to simulate with Voronoi-type models that typically assume a confluent tissue. Here we…
Controlling tissue size by active fracture
Wei Wang, Brian A. Camley
Groups of cells, including clusters of cancerous cells, multicellular organisms, and developing organs, may both grow and break apart. What physical factors control these fractures…
Guiding isotropic active fluids with anisotropic friction
Cody D. Schimming, Brian A. Camley
Inspired by recent experiments of cells accumulating on anisotropic substrates, we study a two-dimensional, compressible, isotropic, active fluid in the presence of anisotropic fri…
Perfect adaptation in eukaryotic gradient sensing using cooperative allosteric binding
Vishnu Srinivasan, Wei Wang, Brian A. Camley
Eukaryotic cells generally sense chemical gradients using the binding of chemical ligands to membrane receptors. In order to perform chemotaxis effectively in different environment…
Competing chemical gradients change chemotactic dynamics and cell distribution
Emiliano Perez Ipiña, Brian A. Camley
Cells are constantly exposed to diverse stimuli-chemical, mechanical, or electrical-that guide their movement. In physiological conditions, these signals often overlap, as seen dur…