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physics.bio-ph2026
Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation
Davey Plugers, Kunihiko Kaneko
Gene expression in cells is stochastic, yet differentiation can display reproducible timing and stable fate commitment. We develop an analytical theory for a previously identified…
physics.bio-ph2025
Evolution of robust cell differentiation under epigenetic feedback
Davey Plugers, Kunihiko Kaneko
In multi-cellular organisms, cells differentiate into multiple types as they divide. States of these cell types, as well as their numbers, are known to be robust to external pertur…