3 papers
stat.AP2026
Distributional Flexibility under Box-Cox Normality: A Theoretical and Empirical Evaluation of the Power-Normal Distribution
Kazushi Maruo, Yusuke Yamaguchi, Ryota Ishii +2
Methods based on Box-Cox models have recently been developed for inference on clinically interpretable treatment effects in clinical trials. These methods model marginal outcome di…
stat.ME2026
Validity of MMRM-based hypothesis testing under missing-not-at-random mechanisms
Kazushi Maruo, Ryota Ishii, Yusuke Yamaguchi +3
In randomized clinical trials with longitudinal continuous outcomes, missing-not-at-random (MNAR) missingness often motivates conservative alternatives to mixed models for repeated…
stat.ME2026
A flexible framework for treatment effect inference in longitudinal clinical studies with skewed outcomes
Kazushi Maruo, Ryota Ishii, Yusuke Yamaguchi +3
Longitudinal continuous outcomes in clinical trials are commonly analyzed using mixed models for repeated measures (MMRM) under normality assumptions. However, many clinical outcom…