10 papers
A multimodal and temporal foundation model for virtual patient representations at healthcare system scale
Andrew Zhang, Tong Ding, Sophia J. Wagner +8
Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified pat…
Evidence-based diagnostic reasoning with multi-agent copilot for human pathology
Luca L. Weishaupt, Chengkuan Chen, Drew F. K. Williamson +8
Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieve…
Mixture of Mini Experts: Overcoming the Linear Layer Bottleneck in Multiple Instance Learning
Daniel Shao, Joel Runevic, Richard J. Chen +4
Multiple Instance Learning (MIL) is the predominant framework for classifying gigapixel whole-slide images in computational pathology. MIL follows a sequence of 1) extracting patch…
Towards Spatial Transcriptomics-driven Pathology Foundation Models
Konstantin Hemker, Andrew H. Song, Cristina Almagro-Pérez +6
Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological a…
NOVA: An Agentic Framework for Automated Histopathology Analysis and Discovery
Anurag J. Vaidya, Felix Meissen, Daniel C. Castro +7
Digitized histopathology analysis involves complex, time-intensive workflows and specialized expertise, limiting its accessibility. We introduce NOVA, an agentic framework that tra…
Do Multiple Instance Learning Models Transfer?
Daniel Shao, Richard J. Chen, Andrew H. Song +4
Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue imag…