3 papers
q-bio.PE2026
A hybrid discrete-continuum modelling approach for the interactions of the immune system with oncolytic viral infections
David Morselli, Marcello E. Delitala, Adrianne L. Jenner +1
Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our…
q-bio.PE2026
The role of viral dynamics and infectivity in models of oncolytic virotherapy for tumours with different motility
David Morselli, Federico Frascoli, Marcello Edoardo Delitala
The use of ad-hoc engineered viruses in the fight against tumours is one of the greatest ideas in cancer therapeutics within the last three decades. Together with other strategies…
q-bio.TO2026
A phenotype-structured mathematical model for the influence of hypoxia on oncolytic virotherapy
David Morselli, Giulia Chiari, Federico Frascoli +1
The effectiveness of oncolytic virotherapy is significantly affected by several elements of the tumour microenvironment, which reduce the ability of the virus to infect cancer cell…