6 papers
Automated Extraction of Pharmacokinetic Parameters from Structured XML Scientific Articles: Enhancing Data Accessibility at Scale
Remya Ampadi Ramachandran, Lisa A. Tell, Sidharth Rai +4
In the field of pharmacology, there is a notable absence of centralized, comprehensive, and up-to-date repositories of PK data. This poses a significant challenge for R&D as it can…
AutoPK: Leveraging LLMs and a Hybrid Similarity Metric for Advanced Retrieval of Pharmacokinetic Data from Complex Tables and Documents
Hossein Sholehrasa, Amirhossein Ghanaatian, Doina Caragea +3
Pharmacokinetics (PK) plays a critical role in drug development and regulatory decision-making for human and veterinary medicine, directly affecting public health through drug safe…
Integrating Protein Sequence and Expression Level to Analysis Molecular Characterization of Breast Cancer Subtypes
Hossein Sholehrasa, Majid Jaberi-Douraki
Breast cancer's complexity and variability pose significant challenges in understanding its progression and guiding effective treatment. This study aims to integrate protein sequen…
HySim-LLM: Embedding-Weighted Fine-Tuning Bounds and Manifold Denoising for Domain-Adapted LLMs
Majid Jaberi-Douraki, Hossein Sholehrasa, Xuan Xu +1
The extraction and standardization of pharmacokinetic (PK) information from scientific literature remain significant challenges in computational pharmacology, which limits the reli…
Predictive Modeling and Explainable AI for Veterinary Safety Profiles, Residue Assessment, and Health Outcomes Using Real-World Data and Physicochemical Properties
Hossein Sholehrasa, Xuan Xu, Doina Caragea +2
The safe use of pharmaceuticals in food-producing animals is vital to protect animal welfare and human food safety. Adverse events (AEs) may signal unexpected pharmacokinetic or to…
Knowledge in Triples for LLMs: Enhancing Table QA Accuracy with Semantic Extraction
Hossein Sholehrasa, Sanaz Saki Norouzi, Pascal Hitzler +1
Integrating structured knowledge from tabular formats poses significant challenges within natural language processing (NLP), mainly when dealing with complex, semi-structured table…