3 papers
q-bio.PE2026
Integrating opportunities and parametrized signatures for improved mutational processes estimation in extended sequence contexts
Ragnhild Laursen, Marta Pelizzola, Lasse Maretty +1
Mutational signatures describe the pattern of mutations over the different mutation types. Each mutation type is determined by a base substitution and the flanking nucleotides to t…
cs.LG2026
MM-algorithms for traditional and convex NMF with Tweedie and Negative Binomial cost functions and empirical evaluation
Elisabeth Sommer James, Asger Hobolth, Marta Pelizzola
Non-negative matrix factorisation (NMF) is a widely used tool for unsupervised learning and feature extraction, with applications ranging from genomics to text analysis and signal…
stat.AP2024
On the Relation Between Autoencoders and Non-negative Matrix Factorization, and Their Application for Mutational Signature Extraction
Ida Egendal, Rasmus Froberg Brøndum, Marta Pelizzola +2
The aim of this study is to provide a foundation to understand the relationship between non-negative matrix factorization (NMF) and non-negative autoencoders enabling proper interp…