7 papers
Dynamical patterns of p53 states driven by PML
Md. Jahoor Alam, Eyad M. AlShammari, R. K. Brojen Singh
Recent studies suggest that PML (Promyelocytic Leukemia) suppresses p53 protein degradation by inhibiting MDM2 protein in the nucleus [1], and regulates a number of biological func…
Phase transition in p53 states induced by glucose
Md. Jahoor Alam, R. K. Brojen Singh
We present p53-MDM2-Glucose model to study spatio-temporal properties of the system induced by glucose. The variation in glucose concentration level triggers the system at differen…
Dynamics of p53 and Wnt cross talk
Md. Zubbair Malik, Shahnawaz Ali, Md. Jahoor Alam +2
We present the mechanism of interaction of Wnt network module, which is responsible for periodic sometogenesis, with p53 regulatory network, which is one of the main regulators of…
Stochastic synchronization of genetic oscillators induced by miRNA
Saurabh Kumar Sharma, Shakti Nath Singh, Md. Jahoor Alam +1
We study two important roles of miRNA as stress inducer and synchronizing agent in regulating diffusively coupled genetic oscillators within stochastic formalism and competition be…
Dynamics of stress p53: Nitric oxide induced transition of states and synchronization
Gurumayum Reenaroy Devi, Md. Jahoor Alam, Ram Ramaswamy +1
We study the temporal and the synchronous behaviours in p53-Mdm2 regulatory network due to the interaction of its complex network components with the nitric oxide molecule. In sing…
The co-existence of states in p53 dynamics driven by miRNA
Md. Jahoor Alam, Shazia Kunvar, R. K. Brojen Singh
The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model network incorporating reactive oxygen species (ROS) is studied. The study shows that miRNA drives p53 dyna…