4 papers · 1 filter
Leveraging Spatial Transcriptomics as Alternative to Manual Annotations for Deep Learning-Based Nuclei Analysis
Kazuya Nishimura, Ryoma Bise, Haruka Hirose +1
Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtai…
Cell-Type Prototype-Informed Neural Network for Gene Expression Estimation from Pathology Images
Kazuya Nishimura, Ryoma Bise, Shinnosuke Matsuo +2
Estimating slide- and patch-level gene expression profiles from pathology images enables rapid and low-cost molecular analysis with broad clinical impact. Despite strong results, e…
Learning Relative Gene Expression Trends from Pathology Images in Spatial Transcriptomics
Kazuya Nishimura, Haruka Hirose, Ryoma Bise +2
Gene expression estimation from pathology images has the potential to reduce the RNA sequencing cost. Point-wise loss functions have been widely used to minimize the discrepancy be…
Towards Spatial Transcriptomics-guided Pathological Image Recognition with Batch-Agnostic Encoder
Kazuya Nishimura, Ryoma Bise, Yasuhiro Kojima
Spatial transcriptomics (ST) is a novel technique that simultaneously captures pathological images and gene expression profiling with spatial coordinates. Since ST is closely relat…