4 papers
Active wetting/de-wetting of focal adhesions on viscoelastic substrates
Ivana Pajic-Lijakovic, Milan Milivojevic, Boris Martinac +2
Cell adhesion to viscoelastic substrates is mediated by focal adhesions (FAs), which dynamically couple actomyosin contractility to the extracellular matrix. Although substrate str…
A phenomenological multiscale framework for orientational interactions and viscoelasticity in migrating epithelial monolayers
Ivana Pajic-Lijakovic, Milan Milivojevic, Peter V. E. McClintock
Collective migration of epithelial monolayers emerges from the interplay between mechanical interactions and biochemical signalling. Here, we present a phenomenological mechanobiol…
Irregular curvature at focal adhesions modulates Piezo1 activity and low frequency ultrasound induced apoptosis in cancer cells
Ivana Pajic-Lijakovic, Milan Milivojevic, Boris Martinac +1
Low-frequency, low intensity ultrasound (LIUS) has emerged as a promising physical modality capable of inducing selective apoptosis of cancer cells, while sparing healthy epithelia…
Marangoni-Driven Redistribution and Activity of Piezo1 Molecules in Epithelial and Cancer Cells
Ivana Pajic-Lijakovic, Milan Milivojevic, Boris Martinac +1
The activity and distribution of Piezo1 molecules, along with the maturity and strength of focal adhesions (FAs), serve as critical factors influencing cell mechanosensing. Notably…