1 citations · 1 across the 4 of their papers we have counts for
4 papers
Randomization Restrictions: Their Impact on Type I Error When Experimenting with Finite Populations
Jonathan J. Chipman, Oleksandr Sverdlov, Diane Uschner
Participants in clinical trials are often viewed as a unique, finite population. Yet, statistical analyses often assume that participants were randomly sampled from a larger popula…
LORDs: Locally Optimal Restricted Designs for Phase I/II Dose-Finding Studies
Oleksandr Sverdlov, Yevgen Ryeznik, Weng Kee Wong
We propose Locally Optimal Restricted Designs (LORDs) for phase I/II dose-finding studies that focus on both efficacy and toxicity outcomes. As an illustrative application, we find…
Estimands for Randomized Discontinuation Designs in Oncology
Ayon Mukherjee, Oleksandr Sverdlov, Ngoc-Thuy Ha +1
Randomized discontinuation design (RDD) is an enrichment strategy commonly used to address limitations of traditional placebo-controlled trials, particularly the ethical concern of…
Incertus.jl -- The Julia Lego Blocks for Randomized Clinical Trial Designs
Yevgen Ryeznik, Oleksandr Sverdlov
In this paper, we present Insertus.jl, the Julia package that can help the user generate a randomization sequence of a given length for a multi-arm trial with a pre-specified targe…