10 citations · 10 across the 2 of their papers we have counts for
2 papers
physics.bio-ph2023
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
Simone Gastaldi, Carmine Rocca, Eleonora Gianquinto +15
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by repla…
q-bio.BM2023★ 10 cited
NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design
Emanuele Casali, Stefano A. Serapian, Eleonora Gianquinto +4
The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3…