8 papers
AblateCell: A Reproduce-then-Ablate Agent for Virtual Cell Repositories
Xue Xia, Chengkai Yao, Mingyu Tsoi +10
Systematic ablations are essential to attribute performance gains in AI Virtual Cells, yet they are rarely performed because biological repositories are under-standardized and tigh…
HarmonyCell: Automating Single-Cell Perturbation Modeling under Semantic and Distribution Shifts
Wenxuan Huang, Mingyu Tsoi, Yanhao Huang +10
Single-cell perturbation studies face dual heterogeneity bottlenecks: (i) semantic heterogeneity--identical biological concepts encoded under incompatible metadata schemas across d…
Reflection Pretraining Enables Token-Level Self-Correction in Biological Sequence Models
Xiang Zhang, Jiaqi Wei, Yuejin Yang +8
Chain-of-Thought (CoT) prompting has significantly advanced task-solving capabilities in natural language processing with large language models. Unlike standard prompting, CoT enco…
Probing Scientific General Intelligence of LLMs with Scientist-Aligned Workflows
Wanghan Xu, Yuhao Zhou, Yifan Zhou +104
Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific do…
Accurate de novo sequencing of the modified proteome with OmniNovo
Yuhan Chen, Shang Qu, Zhiqiang Gao +13
Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modifi…
Scientists' First Exam: Probing Cognitive Abilities of MLLM via Perception, Understanding, and Reasoning
Yuhao Zhou, Yiheng Wang, Xuming He +26
Scientific discoveries increasingly rely on complex multimodal reasoning based on information-intensive scientific data and domain-specific expertise. Empowered by expert-level sci…