4 papers
Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables
Mariyam Khan, Adriaan-Alexander Ludl, Sean Bankier +2
Multivariate Mendelian randomization (MVMR) is a statistical technique that uses sets of genetic instruments to estimate the direct causal effects of multiple exposures on an outco…
Model-based clustering of multi-tissue gene expression data
Pau Erola, Johan LM Björkegren, Tom Michoel
Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from doz…
kruX: Matrix-based non-parametric eQTL discovery
Jianlong Qi, Hassan Foroughi Asl, Johan Bjorkegren +1
The Kruskal-Wallis test is a popular non-parametric statistical test for identifying expression quantitative trait loci (eQTLs) from genome-wide data due to its robustness against…
Identifying the Relevant Nodes Without Learning the Model
Jose M. Pena, Roland Nilsson, Johan Björkegren +1
We propose a method to identify all the nodes that are relevant to compute all the conditional probability distributions for a given set of nodes. Our method is simple, effcient, c…