14 papers
Sample size calculations for multilevel factorial longitudinal cluster randomised trials
Rhys Bowden, Rebecca Walwyn, Jessica Kasza +4
Typically, trials investigate the impact of either an individual-level intervention on participant outcomes, or the impact of a cluster-level intervention on participant outcomes.…
A tutorial on conducting sample size and power calculations for detecting treatment effect heterogeneity in cluster randomized trials with linear mixed models
Mary Ryan Baumann, Monica Taljaard, Patrick J. Heagerty +4
Cluster-randomized trials (CRTs) are a well-established class of designs for evaluating community-based interventions. An essential task in planning these trials is determining the…
Who's Winning? Clarifying Estimands Based on Win Statistics in Cluster Randomized Trials
Kenneth M. Lee, Xi Fang, Fan Li +1
Treatment effect estimands based on win statistics, including the win ratio, win odds, and win difference are increasingly popular targets for summarizing endpoints in clinical tri…
A Bayesian approach to the survivor average causal effect in cluster-randomized crossover trials
Dane Isenberg, Michael O. Harhay, Andrew B. Forbes +3
In cluster-randomized crossover (CRXO) trials, groups of individuals are randomly assigned to two or more sequences of alternating treatments. Since clusters serve as their own con…
Uncovering Treatment Effect Heterogeneity in Pragmatic Gerontology Trials
Changjun Li, Heather Allore, Michael O. Harhay +2
Detecting heterogeneity in treatment response enriches the interpretation of gerontologic trials. In aging research, estimating the effect of the intervention on clinically meaning…
On Anticipation Effect in Stepped Wedge Cluster Randomized Trials
Hao Wang, Xinyuan Chen, Katherine R. Courtright +4
In stepped wedge cluster randomized trials (SW-CRTs), the intervention is rolled out to clusters over multiple periods. A standard approach for analyzing SW-CRTs utilizes the linea…