activity
20222026
most citedAn Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters

54 citations · 61 across the 5 of their papers we have counts for

collaborators

6 papers

physics.med-ph2026

An Uncertainty-Guided Digital Twin Framework for Online Adaptive Proton Therapy in Head and Neck Cancer: A Feasibility Study

Yizhou Wu, Ryan J. Sanford, Huiqiao Xie +12

Objective: Head and neck (HN) proton therapy spans six to seven weeks of anatomical change, while offline replanning takes about a week. We present an uncertainty-guided digital tw…

physics.med-ph2026

A digital-twin framework for forecasting treatment-day imaging with contour uncertainty in adaptive proton radiotherapy

Yizhou Wu, Jie Ding, Justin Roper +6

Head-and-neck anatomy changes over a six-to-seven-week proton course, and the anatomy of a later week cannot be imaged when the plan is made. We present a digital-twin framework th…

physics.med-ph2024★ 7 cited

The status and challenges for prostate SBRT treatments in United States proton therapy centers: An NRG Oncology practice survey

Jiajian Shen, Paige A. Taylor, Carlos E. Vargas +8

A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States t…

physics.med-ph2024

Proton Pencil-Beam Scanning Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG

Wei Liu, Hongying Feng, Paige A. Taylor +13

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combinin…

physics.med-ph2023

A novel inverse algorithm to solve IPO-IMPT of proton FLASH therapy with sparse filters

Nathan Harrison, Minglei Kang, Ruirui Liu +9

Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficu…

physics.med-ph2022★ 54 cited

An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters

Ruirui Liu, Serdar Charyyev, Niklas Wahl +10

Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet t…