3 papers
math.DS2024
Understanding the role of B-cells in CAR T-cell therapy in leukemia through a mathematical model
Sergio Serrano, Roberto Barrio, Álvaro Martínez-Rubio +2
Chimeric Antigen Receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. This paper makes an analytical and numerical study of…
q-bio.TO2024
A mathematical model for fibrous dysplasia: The role of the flow of mutant cells
Mariia Soloviova, Juan Carlos Beltran Vargas, Luis Fernandez de Castro +3
Fibrous dysplasia (FD) is a mosaic non-inheritable genetic disorder of the skeleton in which normal bone is replaced by structurally unsound fibro-osseous tissue. There is no curat…
q-bio.PE2024
First explore, then settle: a theoretical analysis of evolvability as a driver of adaptation
Juan Jiménez-Sánchez, Carmen Ortega-Sabater, Philip K. Maini +2
Evolvability is defined as the ability of a population to generate heritable variation to facilitate its adaptation to new environments or selection pressures. In this article, we…