149 citations · 388 across the 11 of their papers we have counts for
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physics.bio-ph2009★ 49 cited
Thymic selection of T-cell receptors as an extreme value problem
Andrej Kosmrlj, Arup K. Chakraborty, Mehran Kardar +1
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to…
cond-mat.soft2009★ 34 cited
Positive Feedback Regulation Results in Spatial Clustering and Fast Spreading of Active Signaling Molecules on a Cell Membrane
Jayajit Das, Mehran Kardar, Arup K. Chakraborty
Positive feedback regulation is ubiquitous in cell signaling networks, often leading to binary outcomes in response to graded stimuli. However, the role of such feedbacks in cluste…