4 papers
Bayesian Optimization for Identification of Optimal Biological Dose Combinations in Personalized Dose-Finding Trials
James Willard, Shirin Golchi, Erica EM Moodie
Early phase, personalized dose-finding trials for combination therapies seek to identify patient-specific optimal biological dose (OBD) combinations, which are defined as safe dose…
Bayesian Optimization for Personalized Dose-Finding Trials with Combination Therapies
James Willard, Shirin Golchi, Erica E. M. Moodie +2
Identification of optimal dose combinations in early phase dose-finding trials is challenging, due to the trade-off between precisely estimating the many parameters required to fle…
Estimating the Sampling Distribution of Posterior Decision Summaries in Bayesian Clinical Trials
Shirin Golchi, James Willard
Bayesian inference and the use of posterior or posterior predictive probabilities for decision making have become increasingly popular in clinical trials. The current practice in B…
Covariate Adjustment in Bayesian Adaptive Randomized Controlled Trials
James Willard, Shirin Golchi, Erica EM Moodie
In conventional randomized controlled trials, adjustment for baseline values of covariates known to be at least moderately associated with the outcome increases the power of the tr…