most citedThe curious case of A31P, a topology-switching mutant of the Repressor of Primer protein : A molecular dynamics study of its folding and misfolding

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q-bio.BM2024★ 1 cited

The curious case of A31P, a topology-switching mutant of the Repressor of Primer protein : A molecular dynamics study of its folding and misfolding

Olympia-Dialekti Vouzina, Alexandros Tafanidis, Nicholas M. Glykos

The effect of mutations on protein structures is usually rather localized and minor. Finding a mutation that can single-handedly change the fold and/or topology of a protein struct…