11 papers
Continuous quantification of viral plaque dynamics using ultra-large-area label-free imaging enables rapid antiviral susceptibility testing
Merve Eryilmaz, Yuzhu Li, Xiao Wang +8
The plaque reduction assay (PRA) remains the gold standard for antiviral susceptibility testing, evaluating drug potency by measuring reductions in plaque-forming units (PFUs). How…
Compressive single-pixel imaging via a wavelength-multiplexed spatially incoherent diffractive optical processor
Xiao Wang, Yiyang Wu, Yuntian Wang +8
Despite offering high sensitivity, a high signal-to-noise ratio, and a broad spectral range, single-pixel imaging (SPI) is limited by low measurement efficiency and long data-acqui…
Automated HER2 scoring with uncertainty quantification using lensfree holography and deep learning
Che-Yung Shen, Xilin Yang, Yuzhu Li +2
Accurate assessment of human epidermal growth factor receptor 2 (HER2) expression is critical for breast cancer diagnosis, prognosis, and therapy selection; yet, most existing digi…
Deep learning-enhanced dual-mode multiplexed optical sensor for point-of-care diagnostics of cardiovascular diseases
Gyeo-Re Han, Merve Eryilmaz, Artem Goncharov +12
Rapid and accessible cardiac biomarker testing is essential for the timely diagnosis and risk assessment of myocardial infarction (MI) and heart failure (HF), two interrelated cond…
Detection and imaging of chemicals and hidden explosives using terahertz time-domain spectroscopy and deep learning
Xinghe Jiang, Yuhang Li, Yuzhu Li +3
Detecting concealed chemicals and explosives remains a critical challenge in global security. Terahertz time-domain spectroscopy (THz-TDS) offers a promising non-invasive and stand…
Deep learning-enabled virtual multiplexed immunostaining of label-free tissue for vascular invasion assessment
Yijie Zhang, Cagatay Isil, Xilin Yang +6
Immunohistochemistry (IHC) has transformed clinical pathology by enabling the visualization of specific proteins within tissue sections. However, traditional IHC requires one tissu…