4 papers
Associations between pain-management treatments and opioid use disorder risk among Medicaid patients
Kara E. Rudolph, Nicholas T. Williams, Ivan Diaz +7
Introduction: Chronic pain patients are at increased risk of opioid-misuse. Less is known about the unique risk conferred by each pain-management treatment, as treatments are typic…
Identification and estimation of mediational effects of longitudinal modified treatment policies
Brian Gilbert, Katherine L. Hoffman, Nicholas Williams +3
We demonstrate a comprehensive semiparametric approach to causal mediation analysis, addressing the complexities inherent in settings with longitudinal and continuous treatments, c…
Learning Optimal Dynamic Treatment Regimes from Longitudinal Data
Nicholas T. Williams, Katherine L. Hoffman Iván Díaz, Kara E. Rudolph
Studies often report estimates of the average treatment effect. While the ATE summarizes the effect of a treatment on average, it does not provide any information about the effect…
Two-Step Targeted Minimum-Loss Based Estimation for Non-Negative Two-Part Outcomes
Nicholas T. Williams, Richard Liu, Katherine L. Hoffman +3
Non-negative two-part outcomes are defined as outcomes with a density function that have a zero point mass but are otherwise positive. Examples, such as healthcare expenditure and…