16 citations · 52 across the 6 of their papers we have counts for
6 papers
A studentized permutation test in group sequential designs
Long-Hao Xu, Tobias Mütze, Frank Konietschke +1
In group sequential designs, where several data looks are conducted for early stopping, we generally assume the vector of test statistics from the sequential analyses follows (at l…
Estimation methods for estimands using the treatment policy strategy; a simulation study based on the PIONEER 1 Trial
James Bell, Thomas Drury, Tobias Mütze +6
Estimands using the treatment policy strategy for addressing intercurrent events are common in Phase III clinical trials. One estimation approach for this strategy is retrieved dro…
Group sequential designs for negative binomial outcomes
Tobias Mütze, Ekkehard Glimm, Heinz Schmidli +1
Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis,…
Sample size re-estimation incorporating prior information on a nuisance parameter
Tobias Mütze, Heinz Schmidli, Tim Friede
Prior information is often incorporated informally when planning a clinical trial. Here, we present an approach on how to incorporate prior information, such as data from historica…
A studentized permutation test for three-arm trials in the 'gold standard' design
Tobias Mütze, Frank Konietschke, Axel Munk +1
The 'gold standard' design for three-arm trials refers to trials with an active control and a placebo control in addition to the experimental treatment group. This trial design is…
Blinded sample size re-estimation in three-arm trials with 'gold standard' design
Tobias Mütze, Tim Friede
The sample size of a clinical trial relies on information about nuisance parameters such as the outcome variance. When no or only limited information is available, it has been prop…