11 papers
Similarity Analysis of Blood Count Reference Intervals Across Continents Reveals No Reproducible Population or Geography-Linked Structure and Supports Personalised Values
Kunlin Wu, Abicumaran Uthamacumaran, Hector Zenil
Blood reference intervals (RIs) underpin diagnostic interpretation and therapeutic monitoring worldwide. However, many widely used RI systems originate from limited historical coho…
Integrative Adaptive Indexes from Noisy Routine Haematological Markers can Predict and Discriminate Health Status and Biological Age
Santiago Hernández-Orozco, Abicumaran Uthamacumaran, Francisco Hernández-Quiroz +2
For more than two decades, advances in personalised medicine and precision healthcare have largely been based on genomics and other omics data. These strategies aim to tailor inter…
Systematic Reconstruction of Disease Networks from Longitudinal Blood Data for Causal Discovery and Intervention Analysis
David Patrick Duys Montealegre, Alexander Fulton, Mahta Haghighat Ghahfarokhi +2
We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal h…
A High-Fidelity Neurosurgical Training Platform for Bimanual Procedures: A Feasibility Study
Houssem-Eddine Gueziri, Abicumaran Uthamacumaran, Widad Safih +6
Background. Bimanual psychomotor proficiency is fundamental to neurosurgical procedures, yet it remains difficult for trainees to acquire and for educators to objectively evaluate…
XGBoost-Powered Digital Twins Leverage Routine Blood Tests for Early Detection of Cancer and Cardiovascular Disease
Lo Kai Shun John, Riya Nagar, Abicumaran Uthamacumaran +1
Early detection of cancer and cardiovascular diseases is fundamental to improving patient outcomes and reducing healthcare expenditure. Current cancer screening programs are target…
Exhaustive Investigation of CBC-Derived Biomarker Ratios for Clinical Outcome Prediction: The RDW-to-MCHC Ratio as a Novel Mortality Predictor in Critical Care
Dmytro Leontiev, Abicumaran Uthamacumaran, Riya Nagar +1
Ratios of common biomarkers and blood analytes are well established for early detection and predictive purposes. Early risk stratification in critical care is often limited by the…